The Gender, Sexuality and HIV Prevention Center at Ann & Robert H Lurie Children’s Hospital of Chicago works to make the lives of high-risk adolescent populations healthier through clinical care, education and evaluation as well as professional training, research and public health advocacy. These populations include but are not limited to homeless, lesbian, gay, bisexual, transgender and questioning (LGBTQ) people under 28. The Center strives to partner with like-minded organizations creating an environment where clinicians, academics and scientists can collaborate to design projects with public health significance.